BACKGROUND: Hallucinations and delusions that complicate Parkinson’s disease could lead to nursing home placement and are linked to increased mortality. Cognitive impairments are typically associated with the presence of hallucinations but there are no data regarding whether such a relationship exists with delusions. OBJECTIVE: We hypothesized that hallucinations would be associated with executive and visuospatial disturbance. An exploratory examination of cognitive correlates of delusions was also completed to address the question of whether they differ from hallucinations. METHODS: 144 PD subjects (...) completed a neuropsychological battery to assess cognition and the SAPS to examine psychosis. Correlational analyses assessed associations between hallucinations and delusions with cognitive domains. RESULTS: 48 subjects reported psychotic symptoms: 25 experienced hallucinations without delusions, 23 had symptoms dominated by delusions. Severity and/or number of hallucination subtypes were significantly correlated with lower scores in language, memory, attention, executive functioning, and visuospatial ability. Correlations with delusions were non-significant. Tests of differences in the size of the correlations between groups revealed a significant relationship between language and visuospatial performance with hallucinations. CONCLUSIONS: Cognitive correlates of hallucinations and delusions appear to be different in PD, suggesting distinct pathogenic mechanisms and possibly anatomical substrates. Hence, delusions may not share the same associations with dementia as hallucinations. Since this is a new finding, further studies will be needed to confirm our results. (shrink)

Various notions of independence of observables have been proposed within the algebraic framework of quantum field theory. We discuss relationships between these and the recently introduced notion of logical independence in a general operator-algebraic context. We show that C*-independence implies an analogue of classical independence.

Western societies today are coming unmoored in the face of an earth-shaking ethical and cultural paradigm shift. At its core is the question of what it means to be human and how we are meant to live. The old answers are no longer accepted; a dizzying array of options are offered in their stead. Underpinning this smorgasbord of lifestyles is a thicket of unquestioned assumptions, such as the separation of gender from biological sex, which not so long ago would have (...) been universally rejected as radical notions. In the spring of 2019, a group of Orthodox Christian scholars drawn from a wide variety of academic disciplines met together to offer responses to the moral crisis our generation faces, elaborating upon its various forms and facilitating a fuller understanding of some of its theological and philosophical foundations. In doing so they offer support to all those who question the claims that are so forcefully insisted upon today--a clarity that will aid them in standing up and resisting trends that have already shown to be the cause of great suffering and unhappiness. (shrink)

In a recent paper [1], O. F. de Alcantara Bonfim, J. Florencio, and F. C. S´ a Barreto claim to have found numerical evidence of chaos in the motion of a Bohmian quantum particle in a double square-well potential, for a wave function that is a superposition of five energy eigenstates. But according to the result proven here, chaos for this motion is impossible. We prove in fact that for a particle on the line in a superposition of n + (...) 1 energy eigenstates, the Bohm motion x(t) is always quasiperiodic, with (at most) n frequencies. This means that there is a function F (y1, . . . , yn) of period 2π in each of its variables and n frequencies ω1, . . . , ωn such that x(t) = F (ω1t, . . . , ωnt). The Bohm motion for a quantum particle of mass m with wave function ψ = ψ(x, t), a solution to Schrödinger’s equation, is defined by.. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Bibliography of Resources by and about André E. Hellegers*Compiled by Doris Mueller Goldstein (bio)This bibliography is derived from the holdings of the National Reference Center for Bioethics Literature and the BIOETHICSLINE© database (both of which are at the Kennedy Institute of Ethics and supported by the National Library of Medicine); the archives of Lauinger Library, Georgetown University; the Medline databases of the National Library of Medicine; the WorldCat (...) database of OCLC, Dublin, Ohio, and selected Internet sites.Primarily comprised of writings by Dr. Hellegers, the list also includes interviews and media programs in which he participated, as well as writings about him that were written following his death. The arrangement within each section is by date. The 231 authored pieces reflect the transition from Dr. Hellegers’s early career as a researcher in fetal physiology at Johns Hopkins Medical School, where he published his first research report at the age of 29, to the early years of the Kennedy Institute, where he produced so many provocative columns on bioethical issues that influenced the growth of the field.Due to the diversity of sources and the 40-year time span covered, there are some variations in bibliographic style. Time and availability constraints precluded verifying all of the citations with the original documents. Any additions or corrections should be submitted to the compiler.Works Authored by André E. HellegersNo Date Ethical Issues in Sterilization of the Retarded. Unpublished paper.1956Vitamin B12 Serum Level and Pregnancy. American Journal of Clinical Nutrition 4: 440+, 1956. [With Bacon F. Chow and Kunio Okuda] [End Page 89]1957Vitamin B12 Absorption in Pregnancy and in the Newborn. American Journal of Clinical Nutrition 5: 327+, 1957. [With Bacon F. Chow, Robert E. L. Nesbitt, Kunio Okuda, and David W. Smith]1958The Effects of Acute Hypoxia on the Osmotic Pressure of the Plasma. Quarterly Journal of Experimental Physiology 43: 197+, 1958. [With Donald H. Barron, Frederick C. Battaglia, and Giacomo Meschia]Studies on the Absorption of Vitamin B12 in Human Pregnancy with Especial Reference to the Effect of D-Sorbitol. American Journal of Obstetrics and Gynecology 76: 91+, 1958. [With Bacon F. Chow, Harry Prystowsky, and Vernon Wong]1959The Alveolar PCO2 and PO2 in Pregnant and Nonpregnant Women at Altitude. Proceedings of the Society for Clinical Investigation 38: 1010+, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, James Metcalfe, and Harry Prystowsky]A Comparison of the Oxygen Dissociation Curves of the Bloods of Maternal and Fetal Goats at Various pHs. Quarterly Journal of Experimental Physiology 44: 215–21, July 1959. [With Donald Barron, Giacomo Meschia, Harry Prystowsky, and A. Stark Wolkoff]Fetal Blood Studies. XII. On the Relationship Between the Position of the Oxygen Dissociation Curve of Human Fetal Blood and Adult Fetal Hemoglobin. American Journal of Obstetrics and Gynecology 77: 585+, 1959. [With Paul D. Bruns, Julian Cotter, and Harry Prystowsky]Fetal Blood Studies. XIV. A Comparative Study of the Oxygen Dissociation Curve of Nonpregnant, Pregnant and Fetal Human Blood. American Journal of Obstetrics and Gynecology 78: 489–93, September 1959. [With Paul D. Bruns and Harry Prystowsky]Fetal Blood Studies. XVI. On the Changes in Total Osmotic Pressure and Sodium and Potassium Concentration of Amniotic Fluid During the Course of Human Gestation. Surgery, Gynecology and Obstetrics 109: 509–12, October 1959. [With Frederick Battaglia, Paul D. Bruns, Harry Prystowsky, and Clayton Smisson]Further Observations on the Metabolism of Vitamin B12 in Human Pregnancy. American Journal of Obstetrics and Gynecology 77: 1+, 1959. [With Bacon F. Chow, Harry Prystowsky, Bruno Ranke, and Elma Ranke]The Oxygen Dissociation Curves of the Bloods of Adult and Fetal Llamas. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, James Metcalfe, and Harry Prystowsky] [End Page 90]Transfer of Oxygen Across the Sheep Placenta at High Altitude. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, and Harry Prystowsky]Uterine Blood Flow and Metabolism in Pregnant Sheep at High Altitude. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, James Metcalfe, and Harry Prystowsky]Uterine Blood Flow and Metabolism in Unanesthetized Pregnant Sheep. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo... (shrink)

1. L'aspect le plus important du toucher est sa relation au temps et à l'étendue, relation constituée par le mouvement même du toucher. En référence aux conceptions de E. Straus, on expose la distinction entre le toucher et l'être-touché à la lumière d'expériences faites par nous avec des animaux. 2. Le toucher est un être-dans-les-limites-propres et en même temps un franchissement de ces limites, être par lequel l'objet touché est éprouvé à la fois comme „Gegenstand” et comme „Mitseiend”. „Pour le (...) tactile, c'est l'être à deux qui se place au premier rang.” L'affirmation de l'être par le sens du toucher est saisissante dans le cas du se-touchersoi-même, qui est une union exceptionnelle d'activité et de passivité. 3. La reconnaissance tactile de la forme présente elle aussi une dialectique d'activité et de passivité, dialectique qui procède sous la forme d'un développement surmontant le temps, et cela à partir d'un schéma produit dans l'acte même de préhension. On renvoie aux études de V. von Weizsäcker sur le „Gestaltkreis”. Il faut se rappeler aussi l'inquiétude primaire de la main, qui dans le jeu de la main avec un objet devient perdurante. 4. La main peut enserrer un objet. En ce faisant une image schématique tactile est donnée, image qui fonctionne comme hypothèse ou comme principe organisateur du développement prolèptique de l'exploration tactile ultérieure. L'analyse phénoménologique du toucher avec la main se révèle comme une préfiguration de la pensée par jugements synthétiques. Il est donc vrai, comme le remarquait Herder et comme le confirmaient Goldstein et Merleau-Ponty, que la perception telle que l'homme l'effectue et l'existence spirituelle sont identiques. 5. En se référant aux recherches de Révèsz et de Palagyi, on analyse le caractère propre du monde tactil. L'exploration tactile procède selon un véritable développement, donnant lieu à des déterminations anticipatives et rétrospectives qui assurent la continuité de l'événement et de son sens. La perception tactile permet de décrire l'unité continue des phases discontinues objectivement constatables, „comme si” attente et souvenir, jugements provisoires et vérification, fixations conceptuelles et corrections étaient mises en œuvre. 6. Important est l'aspect affectif et émotif des impressions tactiles et leur rapport aux relations interhumaines. 7. Par le toucher l'homme se trouve d'une manière „sensible” en relation personnelle avec cette matérialité des choses qui demeure cachée aux sens-à-distance. Cette participation a un double aspect. Elle est comme le surgissement d'un „état d'âme”, une '‚Befindlichkeit”, mais en même temps elle est le point de départ actif d'un sentir, d'un „comprendre”, d'un „saisir par le dedans”, d'un être-ému, d'un être-frappé par l'objet touché qui se rend présent comme un „quale” propre, comme une matière, comme un être-en-soi. On rappelle le caractère propre du caresser, par lequel l'„être à deux” de l'objet caressé devient complémentaire avec celui du caressant actif. Les concepts usuels par le moyen desquels, dans la vie pratiquement et gnostiquement vécue, sont indiquées les qualités tactiles les plus importantes, ont comme but de nous référer aux propriétés des choses qui prennent place dans le monde géométrique et dans l'espace objectivement mesurable et qui fondent notre orientation naturelle. On rappelle les recherches de von Homborstel au sujet des propriétés internodales des impressions tactiles. Celles-ci nous montrent comment un „savoir” qui accompagne ta perception peut changer une impression sensible. La relation affective, déterminée par un „savoir” nuancé et par un système de valeurs, change la réalité tangible, la substantialité du corps, de la „chair”. Ce changement affectif de la matière, cette „transsubstantiation phénoménale” peut se réaliser facilement par rapport à des objets dont nous savons qu'ils appartiennent ou ont appartenu à quelqu'un. La signification qu'a une chose change la matière de l'objet, objet qui, précisément par le toucher, se rend présent „en chair et en os”. On illustre ceci avec plus de précision grâce aux phénomènes du fétichisme et grâce à de simples expériences de la vie courante. Si nous cherchons un point de vue anthropologique à partir duquel le toucher, dont la main réalise les possibilités, peut prendre un sens, une approche d'un tel point de vue devra s'effectuer à partir de la certitude non-représentable que l'unité ontique de la nature et de l'esprit est dans l'homme la réalité d'une participation possible, participation qui, dans notre existence, n'est qu'indiquée. L'„inquiétude” de la main jamais remplie et toujours chercheuse que nous avons remarquée, est le signe humain de notre existence concrète. Ainsi le toucher nous montre ce que Valéry remarquait à propos de l'esprit : „L'esprit est à la merci du corps, comme les aveugles sont à la merci des voyants.”. (shrink)

We will show that there is a strong form of emergence in cell biology. Beginning with C.D. Broad's classic discussion of emergence, we distinguish two conditions sufficient for emergence. Emergence in biology must be compatible with the thought that all explanations of systemic properties are mechanistic explanations and with their sufficiency. Explanations of systemic properties are always in terms of the properties of the parts within the system. Nonetheless, systemic properties can still be emergent. If the properties of the components (...) within the system cannot be predicted, even in principle, from the behavior of the system's parts within simpler wholes then there also will be systemic properties which cannot be predicted, even in principle, on basis of the behavior of these parts. We show in an explicit case study drawn from molecular cell physiology that biochemical networks display this kind of emergence, even though they deploy only mechanistic explanations. This illustrates emergence and its place in nature. (shrink)

This is a book about the philosophy of Henri Bergson which shows how relevant Bergson is to much contemporary philosophy. The book takes as its point of departure Bergson's insistence on precision in philosophy. It then discusses a variety of topics including laughter, the nature of time as experienced, how intelligence and language should be construed as a pragmatic product of evolution, and the antinomies of reason represented by magic and religion. This is not just another exposition of Bergson's work. (...) It offers an account of why Bergson commanded such a massive reading public in his own day and why he deserves to be read now. Written in a terse and clear style, this book will prove appealing to teachers and students of philosophy, cognitive science, psychology, religious studies and literature. (shrink)

This book is a philosophical commentary on Schopenhauer's "Fourfold Root of the Principle of Sufficient Reason," dealing with each of Schopenhauer's principal ...

Towards the close of Book V of theRepublicPlato tells us that the true philosopher has knowledge and that the objects of knowledge are the Forms. By contrast, the ‘lovers of sights and sounds’, he tells us, have no more than belief, the objects of which are physical particulars. He then goes on to present us with some very radical-sounding assertions about the nature of these physical particulars. They are bearers of opposite properties, he says, in so thorough-going a manner that (...) we cannot say of them that they are nor that they are not: they lie somewhere between being and utter non-being.This passage of theRepublic still awaits an agreed interpretation and I want to suggest as a reason for this that it is usually interpreted in isolation. I will argue that it becomes easier to understand when seen against the background of Plato's developing thought. To be more precise, it makes sense when taken as a rejection by Plato of one of his earlier beliefs: namely, a doctrine of essentialism to be found in thePhaedo.The greater part of this paper then will be an attempt to show thatRepublicV is a rejection of thePhaedo'sdoctrine of essences. Its concluding part will try to explain why that doctrine was rejected. (shrink)

In an essay on pantheism Schopenhauer observes that his chief objection against it is that it says nothing, that it simply enriches language with a superfluous synonym of the word “world.” It can hardly be denied that by this remark the great pessimist, who was himself an atheist, scored a real point. For if a philosopher starts off with the physical world and proceeds to call it God, he has not added anything to the world except a label, a label (...) which, if we take into account the ordinary significance of the word “God,” might well appear unnecessary and superfluous: one might just as pertinently say that the world is the world as that the world is God. Neither the Jew nor the Christian nor the Moslem understand by “God” the physical world, so that, if someone calls the physical world God, he cannot be taken to mean that the world is God according to the Jewish or Christian or Moslem understanding of God. Does he mean any more than that the physical world is ultimately self-explanatory, that no Cause external to the world, no transcendent Being is requisite or admissible, i.e. that there is no God? If that were all there is in pantheism, the latter would indeed be indistinguishable from atheism, and those who called Spinoza an atheist would be fully justified. (shrink)